U of T Kinesiology alum Leila Keshavjee’s startup has landed a sweet deal.

On the recently aired season 13 premiere of reality television show Dragon’s Den, Keshavjee’s healthy ice popsicle startup Happy Pops was offered a $150,000 investment and access to a business accelerator in exchange for 30 per cent equity.

“It was definitely a little more equity than I said I wanted to give up initially going in,” says Keshavjee. “[But] I went with my gut… I have this offer now and I think it’s 100 per cent the best fit.”

Happy Pops was born out of Keshavjee’s desire to create a product that was “a healthier alternative to what’s already out there but still tasted good.”

Through her Kinesiology degree, Keshavjee learned about nutrition and the many ways that sugar can be hidden on food labels. “I wanted to have a product [with ingredients] that anybody could pronounce… There was no hiding.”

While still an undergraduate student at U of T, Keshavjee enrolled in IMC200 — Innovation and Entrepreneurship and IMC390 — Internship in New Venture, where she learned about what it takes to start a business.

Later, she sought advice and support from U of T’s Impact Centre, which she credits with supporting her entrepreneurial adventure. “When you’re running a business, you’re often alone in the startup phase… The opportunities to interact with other entrepreneurs… is one of the most valuable things. You can learn so much from each other.”

PHOTO COURTESY OF LEILA KESHAVJEE

She started her ice pop business after graduating from U of T in 2016, when, with funding from her father, she purchased an ice pop business that had a 1,000-square-foot commercial kitchen but no retail products.

“When I started, I made all the popsicles myself for the first month. So I used to cut the fruit, blend it all, put it in the popsicle mould, seal them, wash all the dishes and all that.” Now that the business has grown, Keshavjee’s role is primarily focused on sales and marketing.

She describes running her own business and building a brand as filled with constant ups and downs. “You could be cold-calling for days. Or, someone could reach out to you and say, ‘Hey, I wanna have you in my store’… Getting people to know who you are as a brand and trust you hasn’t been easy but it’s definitely been a great learning experience.”

On the encouragement of her friends, Keshavjee auditioned for Dragon’s Den in Toronto, which was among the 38 stops the show made across the country. She waited for four hours among many other worthy businesses. She describes the audition process as intense: “You really just have to block out everybody around you and focus on your pitch.”

After being placed on the standby list, she was called and given three days’ notice to appear on Dragon’s Den. She had to prepare her presentation over that weekend, making sure it was entertaining and that the product looked perfect.

Going into the den, Keshavjee was nervous. “I was nauseous, I was sleep-deprived, I was excited… I [had] watched this show for so long.” However, she relaxed when she saw that the investors liked her product.

During her 45 minutes of filming, four of the six investors made offers for Happy Pops.

Keshavjee made her final decision in about a minute. Originally seeking $50,000 for 10 per cent equity, she is finalizing an offer from Arlene Dickinson, whom she knew that she wanted to work with going in, of $150,000 for 30 per cent equity.

To other students looking to start their own businesses, Keshavjee says, “Don’t be afraid to fail and don’t be afraid to take a risk, especially while you’re young. Now is the time to try these things.”

Would you like some crickets with your guac? It may not be long before you see six-legged creatures sharing menu real estate with beef and pork. With the global human population set to reach nine billion by 2050, experts say that conventional protein sources will soon be insufficient to feed everyone. Insects have been proposed by several groups as a protein alternative due to their high nutritional content and economic and environmental benefits.

Over 2,000 insect species are edible; the most commonly consumed species include beetles, caterpillars, wasps, bees, and ants, followed by grasshoppers, locusts, and crickets. Insects are already frequently consumed and are considered a delicacy in 113 countries. In fact, chapulines, a type of grasshopper, are a national dish in Mexico.

Nutritional composition is highly varied among insect species. Within a species, it depends on the stage of metamorphosis, the origin of the insect, and how the insect is prepared. Most edible insects meet the essential protein and energy requirements for human consumption, and they also contain beneficial vitamins, minerals, and fatty acids.

The Nutrient Value Score (NVS) is a tool used to evaluate the nutritional content of food based on energy, protein, fat, and eight micronutrients. A 2016 study used NVS and found that palm weevil larvae and mealworms were significantly healthier than both beef and chicken. The study also revealed that the median iron content of crickets and honeybees were 180 and 850 per cent greater than beef, respectively.

Eating insects may also benefit gut microbiome. Gut microbiota must consume prebiotics, a type of non-digestible fibre, to grow efficiently. The exoskeletons of insects are rich in prebiotic fibre, and they can even be crushed to a powder and added to salad dressings and shakes as a protein and fibre booster.

The attraction of insects as an alternative protein source goes beyond just their nutritional benefits. Compared to conventional livestock, farming insects emits fewer greenhouse gases, requires less land, and causes less water pollution. Insects that are usually considered pests can be farmed for human consumption, which may reduce the use of pesticides for agriculture and alleviate the financial burden of pest control for farmers.

There are even economic benefits: 70 per cent of livestock production costs involve producing feed for animals. Feed conversion efficiency is the measure of an animal’s ability to convert their feed mass into body mass. Insects tend to have higher feed conversion efficiencies than conventional meats. Another 2016 study found that the house cricket has twice the feed conversion efficiency of chickens, four times that of pigs, and 12 times that of cattle.

However, the consumption of insects does not come without drawbacks. Some insects produce toxic compounds and contain heavy metals that can transfer to humans upon consumption. Many insects also have more sodium and saturated fat than conventional meats, which can increase the chance of coronary heart disease. The processing and storage methods for mass insect production are still being investigated.

Despite these drawbacks, consuming insects may be the best alternative protein source in a rapidly growing world. Their high nutrient and protein content make insects an attractive option for regions with high food insecurity and malnourishment. As traditional meat sources face increasing environmental, social, and economic pressures, the choice to eat insects may soon become a necessity.

In 1994, political satirist Christopher Buckley released Thank You for Smoking, a farcical account narrating the woes of tobacco industry lobbyist Nick Naylor that was later adapted into a critically acclaimed film. The twin works accomplished more than simple entertainment. They showcased the inner workings of ‘Big Tobacco’ and the manners in which private industries alter public perception of scientific research.

Although we may imagine ourselves in 2017 to be better informed via the internet of possible corporate chicanery, there are still many ways in which private industries, like Naylor, “filter” the truth.

However, all of this begs the question: why is private funding a concern? The empirical answer is that the source of a research study’s finances may very well bias its conclusions. In one paper, researchers discovered that out of 206 articles on the health effects of non-alcoholic beverages, an industry-backed paper was more than seven times more likely to have a favourable conclusion than a paper with no industry funding.

Much like cigarettes in past decades, junk foods are one of the main comforting or relaxing vices we turn to. And, like their predecessor, there is a scientific consensus that junk foods are harmful to one’s health. Thus, as one might expect, the titans of the junk food industry have spent vast amounts of money funding nutritional research that they hope will either vindicate their products or discover some hitherto-unknown benefit to consumption in large quantities.

A recent target is the US National Institutes of Health (NIH)’s Moderate Alcohol and Cardiovascular Health study. The study will measure a sample group’s cardiovascular health as they consume 15 g of alcohol once a day for 90 months. The results will be compared to a control group that has stayed sober for the same period.

Although it is a publicly funded organization, the NIH was unable to obtain financial backing from the US Congress to carry out the study, forcing it to look for private backers. Unfortunately, this has led to the dubious arrangement of 67 million USD being provided by a cabal composed of companies Anheuser-Busch InBev, Diageo, Pernod Ricard, Heineken, and Carlsberg — all among the largest producers of alcoholic beverages in the world.

Some private entities don’t stop at funding otherwise unaffiliated scientists. For organizations with the means and finances, it is not unheard of to create an entirely new corporate branch or private laboratory dedicated to the research of their choice. Frequently, these labs operate solely for the purposes of research and development of new products, such as Google’s Verily Life Science, which is currently developing smart contact lenses.

Other times, scientists research the health benefits and shortfalls of already existing products. A prime example is Mars, Inc.’s Center for Cocoa Health Science, dedicated to unravelling the multifaceted mysteries of the cocoa bean, since its inception in 2012. Mars, Inc. has published studies in over 140 peer-reviewed academic journals since the early 1980s.

In 2013, one paper analyzed industry and non-industry funded studies on the link between sugar-sweetened beverages and weight gain. They found that industry-funded papers were five times more likely to determine that there was no link.

Furthermore, there is evidence that industry-backed research not only yields biased theoretical results, but it may distract from effective applications as well. A study found that randomized controlled trials proposed by researchers funded by private companies were less than half as likely than independent researchers to propose a change in diet as a method to combat obesity.

All of this points to a need for greater transparency from researchers. “The funding, research, study design, data analysis, manuscript writing, and publication — all of which are part of the process and all require full transparency,” said Dr. Mary R. L’Abbé, Chair of U of T’s Department of Nutritional Sciences. “Not all should be controlled by the funder… Once the study is funded, its conduct, analysis, and publication are based on the study results, not the funder’s needs or objectives.”

But there are more links in the experiment-to-announcement chain than just the researchers themselves. Once conclusions are drawn and test tubes are put back in the cabinet, scholars must have their findings published in an academic journal to see their results applied beyond the laboratory. Of course, academic journals are also staffed and edited by humans who, like researchers, are then also potential recipients of a corporate payoff.

Published in September in the British Medical Journal, a paper by five University Health Network scientists looked at the growing practice of private industries giving financial payments to academic journal editors.

They scrutinized the payments made to 713 editors from 52 American medical journals. The main measure sought was the amount of money in USD received from private pharmaceutical and medical device manufacturers by each study participant in 2014. All participants were at least associate editors in the publishing hierarchy, and all journals were cited as influential.

The authors divided the payments into two categories: research payments, which were for research related activities such as coordinating clinical trial enrolment, and general payments, which were for items more particular to the recipient such as meal or flight reimbursements. Due to their more ambiguous and personal nature, general payments were the focus of the paper.

They discovered that while editors received a median general payment of $11, the mean general payment was a whopping $28,136. This massive right-skew to the data can be explained by the fact that editors in certain esoteric fields, such as endocrinology or cardiology, seemed to attract much more money.

“It is speculative, but certain fields, such as cardiology and orthopedics, have developed innovation in medical devices and this may be driving the increased payments by industry to physician editors in these fields,” explained lead author Dr. Jessica Liu. “Other specialties, such as endocrinology, have innovation in novel drug development to an extent that is not seen in other fields, such as pathology or family medicine, for example.”

Evidently, there is a problem with privately funded research in academia. In her paper, Liu called for editors-in-chief of academic journals to consider the possibility of excluding industry-tied individuals from editorial positions.

However, there are issues with this approach. “This is where a blanket rule on conflict of interest doesn’t exactly work to me. It’s a small world out there after all; if you start eliminating these kinds of conflicts-of-interests you’re not going to be left with many experts,” said Dr. Emanuel Istrate, who is coordinator of VIC172Y1, a course focused on the interactions between society and science and the ethical responsibilities of scientists. “You can find a million people who have no industry ties, but how qualified are they?”

Once more, it seems that the answer lies in increased transparency. “We propose that a good place to start would be for all journals to have accessible, comprehensive, and transparent conflict of interest policies for editors,” said Liu.

Istrate, too, is optimistic. “Now most pharma journals declare conflict of interest or at least declare there is no conflict of interests. Journals are starting to insist a lot more on seeing the reliability of the statistics so that you can’t just have bad statistics or bad sample sizes and just hide it under the rug. So, I’m optimistic things are changing.”

Intermittent fasting (IF) practices have been linked to beneficial health effects, such as increased insulin sensitivity and reduced body weight.

A research team led by Dr. Kyoung-Han Kim at The Hospital for Sick Children and the University of Ottawa Heart Institute demonstrated that the effects of IF without caloric restriction include fat shedding and protection against metabolic dysfunction. The team hopes that the mechanism by which IF works can be studied to treat metabolic conditions such as obesity and type 2 diabetes.

The effects of IF were tested on mice, which were subjected to a two-day unrestricted feeding period followed by one day of fasting. In the first six weeks, the IF mice demonstrated an improved metabolic state and a better ability to regulate blood sugar.

After 16 weeks of the regime, the IF mice weighed less than the control mice who ate the same total volume of food. The researchers noticed that this weight loss corresponded to a loss of white adipose tissue (WAT) and increased thermogenesis, or heat production.

WAT stores energy in the form of fat in your body. In the process of ‘browning,’ it can turn into brown adipose tissue, which is responsible for heat production from fat.

Positive effects were seen in the mice following IF, including WAT browning, which have been linked to a protein called vascular endothelial growth factor (VEGF). It turns out that an IF-induced increase in VEGF triggers the ‘alternative activation’ of a group of cells called macrophages. This increases the level of M2 macrophages in the body, which then are involved in the browning process.

According to the study, it is now accepted that thermogenesis by fat tissues improves metabolism and that VEGF plays a role in this process. Increased levels of VEGF in the WAT of IF mice amplified M2 macrophage activation and thermogenesis.

Obese mice were then subjected to IF without caloric restriction and a high-fat diet, and they displayed similar results after six weeks. This included improved liver function and glucose homeostasis as well as WAT breakdown. These results suggest that IF can also be used to treat obesity, in addition to preventing it.

The researchers also found that IF-induced increases in VEGF were reversible. During fasting, VEGF levels peaked, and during feeding, they decreased to their original concentrations.

When they analyzed the activity of VEGF and M2 macrophages in human tissues, they found a similar correlation.

It must be noted that comparing the effects of IF on mice and on humans is difficult. Periods of fasting lead to both mental and physiological stress, and humans have fundamental differences in baseline metabolic rates and required food intake. However, IF appears to improve both eating behaviour and mood in humans.

The researchers have stated that further rigorous studies are required to examine whether the beneficial effects of IF last after the fasting has been discontinued, the potential harms that may be associated with IF, and whether IF is age- or disease-state dependent. Future studies aim to determine the precise response of human adipose tissues to IF and its association with circadian rhythm, gut microbiome changes, and sleep regulation.

“We plan to investigate the effect of IF on human clinical setting. Based on the results seen from human trials of IF, this could be an alternative treatment method for human obesity and diabetes. However, human study will take some time to initiate,” said co-author Hoon-Ki Sung.